Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation : long-term incidence and outcome

Wolfromm, Alice; Porcher, Raphael; Legoff, Jérome; Peffault de Latour, Régis; Xhaard, Aliénor; de Fontbrune, Flore Sicre; Ribaud, Patricia; Bergeron, Anne; Socié, Gérard; Robin, Marie

doi:10.1016/j.bbmt.2014.04.004

Scientific article

English

Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation : long-term incidence and outcome

ContributorsWolfromm, Alice; Porcher, Raphael

; Legoff, Jérome; Peffault de Latour, Régis; Xhaard, Aliénor; de Fontbrune, Flore Sicre; Ribaud, Patricia; Bergeron, Anne

; Socié, Gérard; Robin, Marie

Published inBiology of blood and marrow transplantation, vol. 20, no. 8, p. 1238-1241

Publication date2014-08

First online date2014-04-13

Abstract

Viral respiratory infections (VRIs) are frequent after hematopoietic stem cell transplantation and constitute a potential cause of mortality. We analyzed the incidence, risk factors, and prognosis of VRIs in a cohort of transplanted patients. More frequent viruses were human coronavirus and human rhinovirus followed by flu-like viruses and adenovirus. Risk factors for death were lymphocytopenia and high steroid dosage.

Keywords

Allogeneic hematopoietic stem cell transplantation
Respiratory viral infections
Adolescent
Adult
Aged
Child
Child, Preschool
Cohort Studies
Female
Hematopoietic Stem Cell Transplantation / adverse effects
Hematopoietic Stem Cell Transplantation / mortality
Humans
Incidence
Male
Middle Aged
Multiplex Polymerase Chain Reaction / methods
Respiratory Tract Infections / diagnosis
Respiratory Tract Infections / etiology
Respiratory Tract Infections / virology
Transplantation Conditioning / adverse effects
Transplantation Conditioning / mortality
Transplantation, Homologous / adverse effects
Transplantation, Homologous / mortality
Treatment Outcome
Young Adult

Affiliation entities

Not a UNIGE publication

Research groups

Maladies interstitielles et de l'immunodéprimé (1057)

Citation (ISO format)

WOLFROMM, Alice et al. Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation : long-term incidence and outcome. In: Biology of blood and marrow transplantation, 2014, vol. 20, n° 8, p. 1238–1241. doi: 10.1016/j.bbmt.2014.04.004