Scientific article

Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism

Published inArchives of internal medicine, vol. 168, no. 19, p. 2131-2136
Publication date2008

BACKGROUND: The revised Geneva score is a fully standardized clinical decision rule (CDR) in the diagnostic workup of patients with suspected pulmonary embolism (PE). The variables of the decision rule have different weights, which could lead to miscalculations in an acute setting. We have validated a simplified version of the revised Geneva score. METHODS: Data from 1049 patients from 2 large prospective diagnostic trials that included patients with suspected PE were used and combined to validate the simplified revised Geneva score. We constructed the simplified CDR by attributing 1 point to each item of the original CDR and compared the diagnostic accuracy of the 2 versions by a receiver operating characteristic curve analysis. We also assessed the clinical utility of the simplified CDR by evaluating the safety of ruling out PE on the basis of the combination of either a low-intermediate clinical probability (using a 3-level scheme) or a "PE unlikely" assessment (using a dichotomized rule) with a normal result on a highly sensitive D-dimer test. RESULTS: The complete study population had an overall prevalence of venous thromboembolism of 23%. The diagnostic accuracy between the 2 CDRs did not differ (area under the curve for the revised Geneva score was 0.75 [95% confidence interval, 0.71-0.78] vs 0.74 [0.70-0.77] for the simplified revised Geneva score). During 3 months of follow-up, no patient with a combination of either a low (0%; 95% confidence interval, 0.0%-1.7%) or intermediate (0%; 0.0%-2.8%) clinical probability, or a "PE unlikely" assessment (0%; 0.0%-1.2%) with the simplified score and a normal result of a D-dimer test was diagnosed as having venous thromboembolism. CONCLUSION: This study suggests that simplification of the revised Geneva score does not lead to a decrease in diagnostic accuracy and clinical utility, which should be confirmed in a prospective study.

  • Adult
  • Aged
  • Algorithms
  • Cohort Studies
  • *Decision Support Techniques
  • Female
  • Forecasting
  • Humans
  • Male
  • Middle Aged
  • *Pulmonary Embolism
  • Retrospective Studies
  • Work Simplification
Citation (ISO format)
KLOK, Frederikus A. et al. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism. In: Archives of internal medicine, 2008, vol. 168, n° 19, p. 2131–2136. doi: 10.1001/archinte.168.19.2131
Updates (1)
ISSN of the journal0003-9926

Technical informations

Creation03/27/2012 9:23:09 AM
First validation03/27/2012 9:23:09 AM
Update time03/14/2023 5:20:02 PM
Status update03/14/2023 5:20:02 PM
Last indexation08/28/2023 9:17:08 PM
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