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Title

Mitofusin 2: a mitochondria-shaping protein with signaling roles beyond fusion

Authors
de Brito, Olga Martins
Published in Antioxidants and Redox Signaling. 2008, vol. 10, no. 3, p. 621-633
Abstract Mitochondria are central organelles in metabolism, signal transduction, and programmed cell death. To meet their diverse functional demands, their shape is strictly regulated by a growing family of proteins that impinge on fission and fusion of the organelle. Mitochondrial fusion depends on Mitofusin (Mfn) 1 and 2, two integral outer-membrane proteins. Although MFN1 seems primarily involved in the regulation of the docking and fusion of the organelle, mounting evidence is implicating MFN2 in multiple signaling pathways not restricted to the regulation of mitochondrial shape. Here we review data supporting a role for this mitochondria-shaping protein beyond fusion, in regulating mitochondrial metabolism, apoptosis, shape of other organelles, and even progression through cell cycle. In conclusion, MFN2 appears a multifunctional protein whose biologic function is not restricted to the regulation of mitochondrial shape.
Keywords Amino Acid SequenceGenetic Diseases, Inborn/physiopathologyHumansMembrane Proteins/chemistry/*physiologyMitochondrial Proteins/chemistry/*physiologyMolecular Sequence DataSequence Homology, Amino AcidSignal Transduction/*physiology
Identifiers
PMID: 18092941
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Structures
Research group Les mitochondries dans la vie cellulaire (850)
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(ISO format)
DE BRITO, Olga Martins, SCORRANO, Luca. Mitofusin 2: a mitochondria-shaping protein with signaling roles beyond fusion. In: Antioxidants and Redox Signaling, 2008, vol. 10, n° 3, p. 621-633. https://archive-ouverte.unige.ch/unige:19044

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Deposited on : 2012-03-27

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