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Impact of discontinuation of contact precautions on healthcare-associated ESBL-producing Escherichia coli in a large tertiary care hospital: an interrupted time-series analysis

ContributorsMusumeci, Stefanoorcid; Grant, Rebeccaorcid; Sobel, Jonathan; Cherkaoui, Abdessalam; Buetti, Niccolo; Harbarth, Stéphan Juergenorcid
Published inClinical infectious diseases, ciaf594
First online date2025-10-29
Abstract

At Geneva University Hospitals, contact precautions for ESBL-producing Escherichia coli were discontinued in 2019. Among 2,336 hospital-associated cases from 2016 to 2024, incidence was 3.1 per 10,000 patient days at baseline and showed no significant increase after discontinuation (slope change -0.04, p=0.14). Results were consistent when limited to clinical isolates.

Keywords
  • ESBL-producing Escherichia coli
  • Contact precautions
  • Healthcare-associated infections
  • Multidrug resistant organisms
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Citation (ISO format)
MUSUMECI, Stefano et al. Impact of discontinuation of contact precautions on healthcare-associated ESBL-producing Escherichia coli in a large tertiary care hospital: an interrupted time-series analysis. In: Clinical infectious diseases, 2025, p. ciaf594. doi: 10.1093/cid/ciaf594
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Additional URL for this publicationhttps://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf594/8305508
Journal ISSN1058-4838
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