In the context of multidisciplinary biomedical research (biological, biophysical, clinical, computational, environmental, human, and social sciences), the framework of scientific integrity and ethics is becoming increasingly complex. This essay explores its dimensions: respect for living beings, societies, and the environment; open science based on FAIR principles and open access; integration of "ethics-by-design" in the face of digital risks and Artificial Intelligence (AI); and reformed and responsible evaluation. Responsibility for this framework lies with both institutions and researchers, who are aware of the political aspects, issues, and criticisms.