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Title

ECG-triggered skeletal muscle stimulation improves hemodynamics and physical performance of heart failure patients

Authors
Lapanashvili, L.
Buziashvili, Y. I.
Matskeplishvili, S. T.
Lobjanidze, T. G.
Bockeria, L. A.
Hess, O. M.
Published in The International Journal of Artificial Organs. 2008, vol. 31, no. 3, p. 244-251
Abstract BACKGROUND: Muscular counterpulsation (MCP) was developed for circulatory assistance by stimulation of peripheral skeletal muscles. We report on a clinical MCP study in patients with and without chronic heart failure (CHF). METHODS AND RESULTS: MCP treatment was applied (30 patients treated, 25 controls, all under optimal therapy) for 30 minutes during eight days by an ECG-triggered, battery-powered, portable pulse generator with skin electrodes inducing light contractions of calf and thigh muscles, sequentially stimulated at early diastole. Hemodynamic parameters (ECG, blood pressure and echocardiography) were measured one day before and one day after the treatment period in two groups: Group 1 (9 MCP, 11 no MCP) with ejection fraction (EF) above 40% and Group 2 (21 MCP, 14 no MCP) below 40%. In Group 2 (all patients suffering from CHF) mean EF increased by 21% (p<0.001) and stroke volume by 13% (p<0.001), while end systolic volume decreased by 23% (p<0.001). In Group 1, the increase in EF (6%) and stroke volume (8%) was also significant (p<0.05) but less pronounced than in Group 2. Physical exercise duration and walking distance increased in Group 2 by 56% and 72%, respectively. CONCLUSIONS: Noninvasive MCP treatment for eight days substantially improves cardiac function and physical performance in patients with CHF.
Keywords AdultCounterpulsation/*methodsElectrocardiographyExercise TestFemaleHeart Failure/physiopathology/*therapyHemodynamicsHumansMaleMiddle AgedMuscle, Skeletal/*physiologyTreatment Outcome
Identifiers
PMID: 18373318
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LAPANASHVILI, L. et al. ECG-triggered skeletal muscle stimulation improves hemodynamics and physical performance of heart failure patients. In: The International Journal of Artificial Organs, 2008, vol. 31, n° 3, p. 244-251. https://archive-ouverte.unige.ch/unige:18986

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Deposited on : 2012-03-27

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