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Copper-Free Asymmetric Allylic Alkylation Using Grignard Reagents on Bifunctional Allylic Bromides

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Published in Organic Letters. 2012, vol. 14, no. 6, p. 1568-1571
Abstract A series of substrates containing a vinylic bromide were employed in a copper-free methodology using bidendate NHC ligands. The desired compounds are generally obtained with good enantioselectivity and good regioselectivity. Importantly the copper-catalyzed system afforded a lower enantioselectivity value. The catalytic products could be transformed into a broad scope of new 1,1-disubstituted olefins in a single step transformation without erosion of the enantioselectivity.
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Other version: http://pubs.acs.org/doi/abs/10.1021/ol300299b
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GRASSI, David, ALEXAKIS, Alexandre. Copper-Free Asymmetric Allylic Alkylation Using Grignard Reagents on Bifunctional Allylic Bromides. In: Organic Letters, 2012, vol. 14, n° 6, p. 1568-1571. https://archive-ouverte.unige.ch/unige:18861

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Deposited on : 2012-03-19

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