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Scientific article
English

Copper-Free Asymmetric Allylic Alkylation Using Grignard Reagents on Bifunctional Allylic Bromides

Published inOrganic letters, vol. 14, no. 6, p. 1568-1571
Publication date2012
Abstract

A series of substrates containing a vinylic bromide were employed in a copper-free methodology using bidendate NHC ligands. The desired compounds are generally obtained with good enantioselectivity and good regioselectivity. Importantly the copper-catalyzed system afforded a lower enantioselectivity value. The catalytic products could be transformed into a broad scope of new 1,1-disubstituted olefins in a single step transformation without erosion of the enantioselectivity.

Citation (ISO format)
GRASSI, David, ALEXAKIS, Alexandre. Copper-Free Asymmetric Allylic Alkylation Using Grignard Reagents on Bifunctional Allylic Bromides. In: Organic letters, 2012, vol. 14, n° 6, p. 1568–1571. doi: 10.1021/ol300299b
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ISSN of the journal1523-7052
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Creation03/19/2012 10:09:00 AM
First validation03/19/2012 10:09:00 AM
Update time03/14/2023 5:09:48 PM
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