The digital revolution has transformed many industries, and healthcare is no exception. In low- and middle-income countries (LMICs), digitization of clinical processes can improve healthcare delivery, patient outcomes, and healthcare system efficiencies. This chapter examines the current state of digitization of clinical pathways in LMICs and highlights the challenges and opportunities in accordance with its implementation. It also examines the impact of digital technologies on various aspects of clinical pathways, such as diagnosis, treatment, monitoring, and follow-up. The potential benefits and risks of digitization are discussed, including data security, privacy, and fairness issues. Based on a review of the relevant literature, the chapter aims to provide an insight into the potential of digitization to revolutionize healthcare in LMICs.