In this 21st century, the enormous scale and extent of social inequalities and ecological devastation prompt us to revisit the relevance and positionality of anthropology as a discipline and a societal project. How then to address systemic change and transformation both within and outside the discipline of anthropology? We, as a collective of anthropologists from Switzerland and Europe, including members of the Swiss Anthropological Association (SAA), the European Association of Social Anthropologists (EASA) and the Swiss Graduate School of Anthropology gathered in Ascona from June 3 to 5, 2024. Hosted by the SAA Interface Commission at the Centro Incontri Umani, we deliberated on the need and potential pathways for a transformative anthropology considering the triple planetary crisis, structural inequalities and deepening conflicts.