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Scientific article
English

Transdermal drug delivery: overcoming the skin's barrier function

Contributors

Naik, Aarti; Kalia, Yogeshvar; Guy, Richard H.

Published in

Pharmaceutical science & technology today, vol. 3, no. 9, p. 318-326

Publication date

2000

Abstract

The skin represents an extraordinary evolutionary feat. Not only does it physically encapsulate the organism and provide a multifunctional interface between us and our surroundings, but it is perpetually engaged in the assembly of a highly efficient homeostatic barrier to the outward loss of water(1). In so doing, it furnishes a membrane that is equally adept at limiting molecular transport both from and into the body. Overcoming this barrier function then, for the purpose of transdermal drug delivery, has been a necessarily challenging task for the pharmaceutical scientist, and one that boasts significant progress.

Keywords

  • Skin barrier
  • Transdermal drug delivery
  • Penetration enhancement
  • Iontophoresis
  • Electroporation
  • Ultrasound

UNIGE affiliation entities

Citation (ISO format)

NAIK, Aarti, KALIA, Yogeshvar, GUY, Richard H. Transdermal drug delivery: overcoming the skin’s barrier function. In: Pharmaceutical science & technology today, 2000, vol. 3, n° 9, p. 318–326. doi: 10.1016/S1461-5347(00)00295-9

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1461-5347
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2downloads

Technical informations

Creation

06/03/2012 12:30:00

First validation

06/03/2012 12:30:00

Update

14/03/2023 17:09:31

Status update

14/03/2023 17:09:31

Last indexation

29/10/2024 19:05:19
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