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Transdermal drug delivery: overcoming the skin's barrier function

Published in Pharmaceutical Science & Technology Today. 2000, vol. 3, no. 9, p. 318-326
Abstract The skin represents an extraordinary evolutionary feat. Not only does it physically encapsulate the organism and provide a multifunctional interface between us and our surroundings, but it is perpetually engaged in the assembly of a highly efficient homeostatic barrier to the outward loss of water(1). In so doing, it furnishes a membrane that is equally adept at limiting molecular transport both from and into the body. Overcoming this barrier function then, for the purpose of transdermal drug delivery, has been a necessarily challenging task for the pharmaceutical scientist, and one that boasts significant progress.
Keywords Skin barrierTransdermal drug deliveryPenetration enhancementIontophoresisElectroporationUltrasound
PMID: 10996573
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NAIK, Aarti, KALIA, Yogeshvar, GUY, Richard H. Transdermal drug delivery: overcoming the skin's barrier function. In: Pharmaceutical Science & Technology Today, 2000, vol. 3, n° 9, p. 318-326. https://archive-ouverte.unige.ch/unige:18772

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Deposited on : 2012-03-09

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