Scientific article

Transdermal drug delivery: overcoming the skin's barrier function

Published inPharmaceutical science & technology today, vol. 3, no. 9, p. 318-326
Publication date2000

The skin represents an extraordinary evolutionary feat. Not only does it physically encapsulate the organism and provide a multifunctional interface between us and our surroundings, but it is perpetually engaged in the assembly of a highly efficient homeostatic barrier to the outward loss of water(1). In so doing, it furnishes a membrane that is equally adept at limiting molecular transport both from and into the body. Overcoming this barrier function then, for the purpose of transdermal drug delivery, has been a necessarily challenging task for the pharmaceutical scientist, and one that boasts significant progress.

  • Skin barrier
  • Transdermal drug delivery
  • Penetration enhancement
  • Iontophoresis
  • Electroporation
  • Ultrasound
Citation (ISO format)
NAIK, Aarti, KALIA, Yogeshvar, GUY, Richard H. Transdermal drug delivery: overcoming the skin’s barrier function. In: Pharmaceutical science & technology today, 2000, vol. 3, n° 9, p. 318–326. doi: 10.1016/S1461-5347(00)00295-9
Main files (1)
Article (Published version)
ISSN of the journal1461-5347

Technical informations

Creation03/06/2012 12:30:00 PM
First validation03/06/2012 12:30:00 PM
Update time03/14/2023 5:09:31 PM
Status update03/14/2023 5:09:31 PM
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