en
Scientific article
English

Influence of steroids on procalcitonin and C-reactive protein in patients with COPD and community-acquired pneumonia

Published inInfection, vol. 36, no. 2, p. 163-166
Publication date2008
Abstract

BACKGROUND: The induction of C-reactive Protein (CRP) may be attenuated by corticosteroids, whereas Procalcitonin (PCT) appears to be unaltered. We investigated, whether in community-acquired pneumonia (CAP) a combined antibiotic-corticosteroid therapy may actually lead to different slopes of decline of these inflammatory markers. PATIENTS AND METHODS: We studied the slopes of decline of PCT and CRP serum levels during 7 consecutive days as well as clinical parameters in a group of patients with CAP on or off corticosteroids. Patients with underlying COPD received systemic corticosteroids (n = 10), while non-COPD patients (n = 10) presenting with CAP alone formed the control group. All patients were treated with antibiotics. RESULTS: At baseline, relevant clinical and laboratory characteristics of the two groups were similar. Regarding the decreasing shapes of the curves from PCT and CRP, no significant differences were found (p-value = 0.48 for the groups for CRP, respectively 0.64 for PCT). All patients showed an uneventful recovery. CONCLUSION: In patients with COPD and CAP, the time courses over 7 days of PCT and CRP showed a nearly parallel decline compared to non-COPD patients with CAP. Contrary to the induction phase, corticosteroids do not modify the time-dependent decay of PCT and CRP when the underlying infectious disease (CAP) is adequately treated.

Keywords
  • Aged
  • Anti-Bacterial Agents/therapeutic use
  • Anti-Inflammatory Agents/therapeutic use
  • C-Reactive Protein/metabolism
  • Calcitonin/blood
  • Community-Acquired Infections/blood/complications/drug therapy
  • Drug Therapy, Combination
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Methylprednisolone/therapeutic use
  • Middle Aged
  • Pilot Projects
  • Pneumococcal Infections/drug therapy
  • Pneumonia/blood/complications/drug therapy
  • Prednisone/therapeutic use
  • Protein Precursors/blood
  • Pulmonary Disease, Chronic Obstructive/blood/complications/drug therapy
Citation (ISO format)
PERREN, Andréas et al. Influence of steroids on procalcitonin and C-reactive protein in patients with COPD and community-acquired pneumonia. In: Infection, 2008, vol. 36, n° 2, p. 163–166. doi: 10.1007/s15010-007-7206-5
Main files (1)
Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal0300-8126
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