Healthcare-associated bloodstream infections are serious complications of central venous access devices (CVADs). Numerous preventative interventions exist, but without high-level evidence. The IVCare adaptive platform trial will provide multiple answers for infection prevention. A prioritization study with infection preventionists using the SHEA CLABSI prevention framework identified priorities for IVCare intervention testing as: vascular access teams, education/competency for CVAD insertion/post-insertion care, sutureless securement, connector type and decontamination method.