Scientific article
Open access

Mitochondrial dynamics and apoptosis: a painful separation

Published inDevelopmental cell, vol. 15, no. 3, p. 341-343
Publication date2008

Reporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined.

  • Animals
  • Apoptosis/physiology
  • Cytochromes c/metabolism
  • Cytoskeletal Proteins/metabolism
  • Mitochondria/metabolism/ultrastructure
  • Mitochondrial Proteins/metabolism
  • Proto-Oncogene Proteins c-bcl-2/genetics/metabolism
Citation (ISO format)
JAMES, Dominic I, MARTINOU, Jean-Claude. Mitochondrial dynamics and apoptosis: a painful separation. In: Developmental cell, 2008, vol. 15, n° 3, p. 341–343. doi: 10.1016/j.devcel.2008.08.011
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Article (Published version)
ISSN of the journal1878-1551

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