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Title

Mitochondrial dynamics and apoptosis: a painful separation

Authors
James, Dominic I
Published in Developmental cell. 2008, vol. 15, no. 3, p. 341-3
Abstract Reporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined.
Keywords AnimalsApoptosis/physiologyCytochromes c/metabolismCytoskeletal Proteins/metabolismMitochondria/metabolism/ultrastructureMitochondrial Proteins/metabolismProto-Oncogene Proteins c-bcl-2/genetics/metabolism
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PMID: 18804432
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JAMES, Dominic I, MARTINOU, Jean-Claude. Mitochondrial dynamics and apoptosis: a painful separation. In: Developmental cell, 2008, vol. 15, n° 3, p. 341-3. https://archive-ouverte.unige.ch/unige:18690

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Deposited on : 2012-03-06

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