Scientific article
OA Policy
English

Mitochondrial dynamics and apoptosis: a painful separation

Published inDevelopmental cell, vol. 15, no. 3, p. 341-343
Publication date2008
Abstract

Reporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined.

Keywords
  • Animals
  • Apoptosis/physiology
  • Cytochromes c/metabolism
  • Cytoskeletal Proteins/metabolism
  • Mitochondria/metabolism/ultrastructure
  • Mitochondrial Proteins/metabolism
  • Proto-Oncogene Proteins c-bcl-2/genetics/metabolism
Citation (ISO format)
JAMES, Dominic I, MARTINOU, Jean-Claude. Mitochondrial dynamics and apoptosis: a painful separation. In: Developmental cell, 2008, vol. 15, n° 3, p. 341–343. doi: 10.1016/j.devcel.2008.08.011
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN1878-1551
518views
272downloads

Technical informations

Creation27/02/2012 15:20:00
First validation27/02/2012 15:20:00
Update time14/03/2023 17:09:16
Status update14/03/2023 17:09:16
Last indexation29/10/2024 19:04:19
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack