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Scientific article
Open access
English

Mitochondrial dynamics and cancer

Published inSeminars in cancer biology, vol. 19, no. 1, p. 50-56
Publication date2009
Abstract

Mitochondrial morphology is regulated by continuous fusion and fission events that are essential for maintaining a normal mitochondrial function. If the last years have witnessed major discoveries in the characterization of the fission and fusion machineries, little is known about the physiological role of mitochondrial dynamics. In this review we report the results showing evidences of relationships between mitochondrial dynamics and cellular metabolism, autophagy or apoptosis. We discuss how different mitochondrial alterations observed in cancer cells could be linked to unbalanced mitochondrial fission or fusion events and how this could impinge on key essential cellular processes, thereby contributing to tumorigenesis.

Keywords
  • Animals
  • Apoptosis/physiology
  • Autophagy/physiology
  • Cell Cycle/physiology
  • Energy Metabolism/physiology
  • Humans
  • Mitochondria/physiology
  • Mitochondrial Proteins/metabolism
  • Neoplasms/metabolism
  • Proto-Oncogene Proteins c-bcl-2/metabolism
Citation (ISO format)
GRANDEMANGE, Stéphanie, HERZIG, Sébastien, MARTINOU, Jean-Claude. Mitochondrial dynamics and cancer. In: Seminars in cancer biology, 2009, vol. 19, n° 1, p. 50–56. doi: 10.1016/j.semcancer.2008.12.001
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Article (Published version)
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ISSN of the journal1044-579X
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