UNIGE document Scientific Article
previous document  unige:18686  next document
add to browser collection
Title

Mitochondrial outer-membrane permeabilization and remodelling in apoptosis

Authors
Published in The International Journal of Biochemistry & Cell Biology. 2009, vol. 41, no. 10, p. 1884-9
Abstract Many human pathologies are associated with defects in mitochondria such as diabetes, neurodegenerative diseases or cancer. This tiny organelle is involved in a plethora of processes in mammalian cells, including energy production, lipid metabolism and cell death. In the so-called intrinsic apoptotic pathway, the outer mitochondrial membrane (MOM) is premeabilized by the pro-apoptotic Bcl-2 members Bax and Bak, allowing the release of apoptogenic factors such as cytochrome c from the inter-membrane space into the cytosol. At the same time, mitochondria fragment in response to Drp-1 activation suggesting that mitochondrial fission could play a role in mitochondrial outer-membrane permeabilization (MOMP). In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP.
Keywords AnimalsApoptosis/physiologyGTP Phosphohydrolases/metabolism/physiologyHumansMitochondria/metabolismMitochondrial Membranes/metabolismBcl-2-Associated X Protein/metabolism/physiology
Identifiers
PMID: 19439192
Full text
Article (Published version) (381 Kb) - public document Free access
Structures
Citation
(ISO format)
JOURDAIN, Alexis, MARTINOU, Jean-Claude. Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. In: The International Journal of Biochemistry & Cell Biology, 2009, vol. 41, n° 10, p. 1884-9. https://archive-ouverte.unige.ch/unige:18686

230 hits

113 downloads

Update

Deposited on : 2012-03-06

Export document
Format :
Citation style :