Scientific article
Open access

Mitochondrial outer-membrane permeabilization and remodelling in apoptosis

Published inInternational journal of biochemistry & cell biology, vol. 41, no. 10, p. 1884-1889
Publication date2009

Many human pathologies are associated with defects in mitochondria such as diabetes, neurodegenerative diseases or cancer. This tiny organelle is involved in a plethora of processes in mammalian cells, including energy production, lipid metabolism and cell death. In the so-called intrinsic apoptotic pathway, the outer mitochondrial membrane (MOM) is premeabilized by the pro-apoptotic Bcl-2 members Bax and Bak, allowing the release of apoptogenic factors such as cytochrome c from the inter-membrane space into the cytosol. At the same time, mitochondria fragment in response to Drp-1 activation suggesting that mitochondrial fission could play a role in mitochondrial outer-membrane permeabilization (MOMP). In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP.

  • Animals
  • Apoptosis/physiology
  • GTP Phosphohydrolases/metabolism/physiology
  • Humans
  • Mitochondria/metabolism
  • Mitochondrial Membranes/metabolism
  • Bcl-2-Associated X Protein/metabolism/physiology
Citation (ISO format)
JOURDAIN, Alexis, MARTINOU, Jean-Claude. Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. In: International journal of biochemistry & cell biology, 2009, vol. 41, n° 10, p. 1884–1889. doi: 10.1016/j.biocel.2009.05.001
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Article (Published version)
ISSN of the journal1357-2725

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