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Mitochondrial outer-membrane permeabilization and remodelling in apoptosis

Published in The International Journal of Biochemistry & Cell Biology. 2009, vol. 41, no. 10, p. 1884-9
Abstract Many human pathologies are associated with defects in mitochondria such as diabetes, neurodegenerative diseases or cancer. This tiny organelle is involved in a plethora of processes in mammalian cells, including energy production, lipid metabolism and cell death. In the so-called intrinsic apoptotic pathway, the outer mitochondrial membrane (MOM) is premeabilized by the pro-apoptotic Bcl-2 members Bax and Bak, allowing the release of apoptogenic factors such as cytochrome c from the inter-membrane space into the cytosol. At the same time, mitochondria fragment in response to Drp-1 activation suggesting that mitochondrial fission could play a role in mitochondrial outer-membrane permeabilization (MOMP). In this review, we will discuss the link that could exist between mitochondrial fission and fusion machinery, Bcl-2 family members and MOMP.
Keywords AnimalsApoptosis/physiologyGTP Phosphohydrolases/metabolism/physiologyHumansMitochondria/metabolismMitochondrial Membranes/metabolismBcl-2-Associated X Protein/metabolism/physiology
PMID: 19439192
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JOURDAIN, Alexis, MARTINOU, Jean-Claude. Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. In: The International Journal of Biochemistry & Cell Biology, 2009, vol. 41, n° 10, p. 1884-9. doi: 10.1016/j.biocel.2009.05.001 https://archive-ouverte.unige.ch/unige:18686

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Deposited on : 2012-03-06

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