Pancreatic cancer (PC) is an aggressive disease with a poor prognosis, characterized by a median survival of 6 to 8 months and a 5-year survival rate of approximately 15%. In Switzerland, around 1,700 new cases and 1,400 deaths are reported each year. Late diagnosis- largely due to the absence of specific symptoms and validated biomarkers-limits the availability of curative treatment options. This article summarizes recent advances in the multidisciplinary management of PC, detailing the diagnostic workup and therapeutic approaches: imaging, endoscopic techniques, pathology, minimally invasive surgery, ablative radiotherapy, and standard or molecularly guided systemic therapies. Despite notable progress and promising prospects, PC remains a significant challenge in oncology.