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Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation

Wider, C.
Bloch, J.
Published in Parkinsonism & Related Disorders. 2008, vol. 14, no. 2, p. 114-9
Abstract OBJECTIVE: To describe the long-term outcome in 50 consecutive advanced Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS). METHOD: Assessments were carried out at baseline, 6 months, 2 years, and 5 years postoperatively. RESULTS: Compared to baseline scores without medication, we found a highly significant improvement of UPDRS III with stimulation, maintained at 5 years (p<0.001). This improvement, however, tended to diminish over time. Dyskinesia and off periods were also improved (p<0.0001 for both). Seventeen patients died during follow-up, who tended to be older at surgery (p<0.01). CONCLUSIONS: STN-DBS is an effective treatment for advanced PD patients, and the beneficial effect is maintained at 5 years. However, worsening occurs over time due to disease progression.
Keywords AgedAntiparkinson Agents/therapeutic useCohort StudiesDeep Brain Stimulation/adverse effectsElectrodes, ImplantedFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMicroelectrodesMiddle AgedMovement/physiologyParkinson Disease/mortality/therapyProspective StudiesStereotaxic TechniquesSubthalamic NucleusSurvival AnalysisTreatment Outcome
PMID: 17822940
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Research group Groupe Pierre Burkhard (neurologie) (154)
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WIDER, C. et al. Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation. In: Parkinsonism & Related Disorders, 2008, vol. 14, n° 2, p. 114-9. doi: 10.1016/j.parkreldis.2007.06.012 https://archive-ouverte.unige.ch/unige:1866

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Deposited on : 2009-06-02

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