Modern management of the full-mouth rehabilitation of worn dentition emphasizes minimally invasive and adhesive techniques, especially in treating younger patients or interceptive cases. CAD/CAM composite resins have become valuable for such treatments due to their balance between functional restoration and esthetic enhancement. These materials blend seamlessly with the natural dentition, providing satisfactory esthetic results and enhancing restoration stability and longevity, exploiting the advantages of adhesive techniques. Moreover, CAD/CAM composite resins are more economical than their ceramic counterparts, making them a sustainable option for extensive rehabilitations. The present article analyzes the rationale for using CAD/CAM composite resin materials in full-mouth minimally invasive rehabilitations. It also presents the follow-up of two previously published cases (one up to 8 years and the other up to 4 years), and a new clinical case illustrating a step-by-step, fully digital workflow. CAD/CAM composite resins offer numerous advantages such as efficient and precise fabrication, the ability to be milled into very thin layers without compromising strength, and ease of reparability. They can be considered the elective material in additive approaches, minimizing or eliminating the need for tooth preparation. However, challenges may arise with natural undercuts in worn dentition, requiring careful planning. The results of studies on CAD/CAM composite resins nowadays show them to be a viable and effective option, offering the possibility of obtaining excellent functional and esthetic results.