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[(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma

Casanova, Nathalie
Haller, Guy
Rouzaud, Michel
Nouet, Philippe
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Published in Radiation oncology. 2008, vol. 3, 44
Abstract BACKGROUND: To compare morphological gross tumor volumes (GTVs), defined as pre- and postoperative gadolinium enhancement on T1-weighted magnetic resonance imaging to biological tumor volumes (BTVs), defined by the uptake of (18)F fluoroethyltyrosine (FET) for the radiotherapy planning of high-grade glioma, using a dedicated positron emission tomography (PET)-CT scanner equipped with three triangulation lasers for patient positioning. METHODS: Nineteen patients with malignant glioma were included into a prospective protocol using FET PET-CT for radiotherapy planning. To be eligible, patients had to present with residual disease after surgery. Planning was performed using the clinical target volume (CTV = GTV union or logical sum BTV) and planning target volume (PTV = CTV + 20 mm). First, the interrater reliability for BTV delineation was assessed among three observers. Second, the BTV and GTV were quantified and compared. Finally, the geometrical relationships between GTV and BTV were assessed. RESULTS: Interrater agreement for BTV delineation was excellent (intraclass correlation coefficient 0.9). Although, BTVs and GTVs were not significantly different (p = 0.9), CTVs (mean 57.8 +/- 30.4 cm(3)) were significantly larger than BTVs (mean 42.1 +/- 24.4 cm(3); p < 0.01) or GTVs (mean 38.7 +/- 25.7 cm(3); p < 0.01). In 13 (68%) and 6 (32%) of 19 patients, FET uptake extended >or= 10 and 20 mm from the margin of the gadolinium enhancement. CONCLUSION: Using FET, the interrater reliability had excellent agreement for BTV delineation. With FET PET-CT planning, the size and geometrical location of GTVs and BTVs differed in a majority of patients.
Keywords AdultAgedBrain Neoplasms/radionuclide imaging/radiotherapyFemaleFluorine Radioisotopes/diagnostic useGlioma/radionuclide imaging/radiotherapyHumansMaleMiddle AgedObserver VariationPositron-Emission TomographyRadiopharmaceuticals/diagnostic useRadiotherapy Planning, Computer-Assisted/methodsTyrosine/diagnostic use
PMID: 19108742
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Research groups Ciblage tumoral par anticorps, peptides et nucléotides radiomarqués (221)
Groupe Mirabell Raymond (radio-oncologie) (685)
Groupe Ratib Osman (nouvelles techniques d'imagerie moléculaire) (819)
Groupe Weber Damien (oncologie pédiatrique) (894)
Imagerie Médicale (TEP et TEMP) (542)
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WEBER, Damien et al. [(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma. In: Radiation oncology, 2008, vol. 3, p. 44. doi: 10.1186/1748-717X-3-44 https://archive-ouverte.unige.ch/unige:1863

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Deposited on : 2009-06-02

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