Scientific article
OA Policy
English

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke : a clinical practice guideline

Errata
  • The autors have changed the wording in the “What you need to know” box and infographic to suggest that, after 10-21 days of dual antiplatelet therapy, patients should continue on single antiplatelet therapy alone. They have also changed the wording of the bleeding outcomes in the infographic to be more specific about severity of bleeding. “Extracranial haemorrhage” has been changed to “Moderate or major bleeding,” and “Extracranial bleeding” has been changed to “Minor bleeding.”
  • DOI : 10.1136/bmj.l103
  • PMID : 30630830
Published inBMJ. British medical journal, vol. 363, k5130
First online date2018-12-18
Abstract

What is the role of dual antiplatelet therapy after high risk transient ischaemic attack or minor stroke? Specifically, does dual antiplatelet therapy with a combination of aspirin and clopidogrel lead to a greater reduction in recurrent stroke and death over the use of aspirin alone when given in the first 24 hours after a high risk transient ischaemic attack or minor ischaemic stroke? An expert panel produced a strong recommendation for initiating dual antiplatelet therapy within 24 hours of the onset of symptoms, and for continuing it for 10-21 days. Current practice is typically to use a single drug

Keywords
  • Aspirin / administration & dosage
  • Brain Ischemia / drug therapy
  • Brain Ischemia / prevention & control
  • Clopidogrel / administration & dosage
  • Humans
  • Ischemic Attack, Transient / drug therapy
  • Ischemic Attack, Transient / prevention & control
  • Platelet Aggregation Inhibitors / administration & dosage
  • Practice Guidelines as Topic
  • Recurrence
  • Secondary Prevention
  • Stroke / drug therapy
  • Stroke / prevention & control
  • Time Factors
Citation (ISO format)
PRASAD, Kameshwar et al. Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke : a clinical practice guideline. In: BMJ. British medical journal, 2018, vol. 363, p. k5130. doi: 10.1136/bmj.k5130
Main files (1)
Article (Published version)
accessLevelPublic
Updates (1)
Erratum
accessLevelPublic
Identifiers
Additional URL for this publicationhttps://www.bmj.com/lookup/doi/10.1136/bmj.k5130
Journal ISSN0959-8138
42views
983downloads

Technical informations

Creation14/03/2025 17:04:04
First validation18/06/2025 15:45:01
Update18/06/2025 15:45:01
Status update18/06/2025 15:45:01
Last indexation18/06/2025 15:45:02
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack