Cell-cell fusion is a fundamental biological process present in most eukaryotic species. In walled organisms, a critical step includes the degradation of the cell wall, which surround the plasma membrane to protect cell integrity. In the fission yeast, Schizosaccharomyces pombe (S. pombe), cells undergo fusion during sexual reproduction. Cell wall degradation relies on the formation of an actin aster nucleated by formin Fus1, which promotes local accumulation of glucanase-containing vesicles through transport by the class V myosin, Myo52. The work presented here sheds light on the mechanisms underlying fusion focus formation and cell wall degradation. Through systematic imaging, we computed a spatiotemporal map of the actin fusion focus that revealed a dual role of Myo52 during the fusion process. Myo52 both carries vesicles to the site of fusion but also interacts, directly or indirectly, with Fus1, participating in fusion focus compaction.