Scientific article
English

X-rays can trigger the FLASH effect : Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

Published inRadiotherapy and oncology, vol. 129, no. 3, p. 582-588
Publication date2018-12
First online date2018-08-31
Abstract

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.

Keywords
  • Cognitive impairment
  • Radiation-induced brain injury
  • Synchrotron radiation
  • Ultra-high dose-rate X-ray radiation
Affiliation entities Not a UNIGE publication
Citation (ISO format)
MONTAY-GRUEL, Pierre et al. X-rays can trigger the FLASH effect : Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice. In: Radiotherapy and oncology, 2018, vol. 129, n° 3, p. 582–588. doi: 10.1016/j.radonc.2018.08.016
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0167-8140
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