Scientific article
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English

Pitfalls in definitions on respiratory viruses and particularities of Adenovirus infection in hematopoietic cell transplantation patients : Recommendations from the EBMT practice harmonization and guidelines committee

Published inCurrent research in translational medicine, vol. 72, no. 3, 103461
Publication date2024-09
First online date2024-07-14
Abstract

In 2023, the EBMT Practice harmonization and Guidelines Committee partnered with the EBMT Infection Diseases Working Party (IDWP) to undertake the task of delivering best practice recommendations, aiming to harmonize by expert consensus, the already existing definitions and future epidemiological and clinical studies among centers of the EBMT network. To attain this objective, a group of experts in the field was convened. The workgroup identified and discussed some critical aspects in definitions of community-acquired respiratory viruses (CARV) and adenovirus (ADV) infections in recipient of hematopoietic cell transplant (HCT). The methodology involved literature review and expert consensus. For CARV, expert consensus focused on defining infection severity, infection duration, and establishing criteria for lower respiratory tract disease (LRTD). For ADV, the expert consensus focused on surveillance methods and the definitions of ADV infection, certainty levels of disease, response to treatment, and attributable mortality. This consensus workshop provided indications to EBMT community aimed at facilitating data collection and consistency in the EBMT registry for respiratory viral infectious complications.

Keywords
  • Adenovirus
  • Allogeneic hematopoietic cell transplantation (allo-HCT)
  • Best practice EBMT recommendations
  • Cellular therapy
  • Community acquired respiratory virus
  • Definitions
  • Harmonization workshop
  • Human metapneumovirus
  • Influenza
  • Lower respiratory tract disease
  • Parainfluenza virus
  • Respiratory syncytial virus (RSV)
  • SARS-CoV-2
  • Humans
  • Hematopoietic Stem Cell Transplantation / adverse effects
  • Respiratory Tract Infections / therapy
  • Respiratory Tract Infections / diagnosis
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / virology
  • Adenoviridae Infections / therapy
  • Adenoviridae Infections / diagnosis
  • Adenoviridae Infections / epidemiology
  • Community-Acquired Infections / therapy
  • Community-Acquired Infections / epidemiology
  • Community-Acquired Infections / diagnosis
  • Practice Guidelines as Topic
  • Consensus
  • Adenovirus Infections, Human / diagnosis
  • Adenovirus Infections, Human / therapy
  • Adenovirus Infections, Human / epidemiology
  • Adenoviridae / isolation & purification
Citation (ISO format)
PIÑANA, José Luis et al. Pitfalls in definitions on respiratory viruses and particularities of Adenovirus infection in hematopoietic cell transplantation patients : Recommendations from the EBMT practice harmonization and guidelines committee. In: Current research in translational medicine, 2024, vol. 72, n° 3, p. 103461. doi: 10.1016/j.retram.2024.103461
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Article (Published version)
Identifiers
Journal ISSN2452-3186
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160downloads

Technical informations

Creation09/12/2024 14:29:25
First validation05/02/2025 13:09:07
Update22/04/2025 07:15:15
Status update22/04/2025 07:15:15
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