Women are widely assumed to be more talkative than men. Challenging this assumption, Mehl et al. (2007) provided empirical evidence that men and women do not differ significantly in their daily word use, speaking about 16,000 words per day (WPD) each. However, concerns were raised that their sample was too small to yield generalizable estimates and too age and context homogeneous to permit inferences beyond college students. This registered report replicated and extended the previous study of binary gender differences in daily word use to address these concerns. Across 2,197 participants (more than five-fold the original sample size), pooled over 22 samples (631,030 ambient audio recordings), men spoke on average 11,950 WPD and women 13,349 WPD, with very large individual differences (<100 to >120,000 WPD). The estimated gender difference (1,073 WPD; d = 0.13; 95% CI [316, 1,824]) was about twice as large as in the original study. Smaller differences emerged among adolescent (513 WPD), emerging adult (841 WPD), and older adult (−788 WPD) participants, but a substantially larger difference emerged for participants in early and middle adulthood (3,275 WPD; d = 0.32). Despite the considerable sample size(s), all estimates carried large statistical uncertainty and, except for the gender difference in early and middle adulthood, provide inconclusive evidence regarding whether the two genders ultimately speak a practically equivalent number of WPD, based on the preregistered ±1,000 WPD regions of practical equivalence criterion. Experienced stress had no meaningful effect on the gender difference, and no clear pattern emergedas towhetherthe genderdifference is accentuated for subjectively rated compared with objectively observed talkativeness.