Cell dispersal in biofilms: an extracellular DNA masks nature&#039;s strongest glue

Kirkpatrick, Clare; Viollier, Patrick

doi:10.1111/j.1365-2958.2010.07268.x

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Title		Cell dispersal in biofilms: an extracellular DNA masks nature's strongest glue
Authors		Kirkpatrick, Clare Viollier, Patrick
Published in		Molecular Microbiology. 2010, vol. 77, no. 4, p. 801-804
Abstract		Summary Growth in biofilms provides bacterial species with many advantages over growth in suspension, e.g. colonization of nutrient-rich areas. In the alpha-proteobacterium Caulobacter crescentus biofilm formation is facilitated through its asymmetric cell division, where one daughter cell becomes a motile flagellated swarmer cell able to colonize new surfaces while the other remains as a stalked cell attached to the substrate through the adhesive holdfast. The Caulobacter biofilm consists of stalked cells arranged either in a monolayer or in a multicellular 'mushroom' structure. In this issue of Molecular Microbiology, Berne et al. demonstrate that extracellular DNA (eDNA) from lysed cells prevents biofilm maturation. eDNA masks the adhesive properties of newly synthesized holdfast to enable the escape of swarmer cells from the biofilm. By contrast, holdfasts on previously attached stalked cells remain unaffected by eDNA. Surprisingly, the inhibitory effect was genus-specific, as only DNA from Caulobacter, but not from other genera, could interfere with biofilm maturation. This study reveals a new role for DNA in biofilms, as a regulatory rather than a structural component, and a novel mechanism to facilitate the escape of cells from biofilms. A compelling case is made for the existence of a new type of genus-specific 'macromolecular language'.
Identifiers		DOI: 10.1111/j.1365-2958.2010.07268.x PMID: 20572936
Full text		Article (Published version) (188 Kb) - Free access
Structures		Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire
Research group		Régulation du cycle cellulaire dans C.crescentus, une bactérie asymétrique (895)
Citation (ISO format)		KIRKPATRICK, Clare, VIOLLIER, Patrick. Cell dispersal in biofilms: an extracellular DNA masks nature's strongest glue. In: Molecular Microbiology, 2010, vol. 77, n° 4, p. 801-804. doi: 10.1111/j.1365-2958.2010.07268.x https://archive-ouverte.unige.ch/unige:18250