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Scientific article
English

Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation

Published inAngewandte Chemie, vol. 51, no. 4, p. 1055-1058
Publication date2012
Abstract

A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.

Keywords
  • Alkylation
  • Asymmetric catalysis
  • Copper
  • Enynes
  • Grignard reagents
Citation (ISO format)
LI, Hailing, ALEXAKIS, Alexandre. Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation. In: Angewandte Chemie, 2012, vol. 51, n° 4, p. 1055–1058. doi: 10.1002/anie.201107129
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ISSN of the journal1433-7851
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Creation01/26/2012 3:24:00 PM
First validation01/26/2012 3:24:00 PM
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