Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation

Li, Hailing; Alexakis, Alexandre

doi:10.1002/anie.201107129

Scientific article

English

Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation

ContributorsLi, Hailing; Alexakis, Alexandre

Published inAngewandte Chemie, vol. 51, no. 4, p. 1055-1058

Publication date2012

Abstract

A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.

Keywords

Alkylation
Asymmetric catalysis
Copper
Enynes
Grignard reagents

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

LI, Hailing, ALEXAKIS, Alexandre. Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation. In: Angewandte Chemie, 2012, vol. 51, n° 4, p. 1055–1058. doi: 10.1002/anie.201107129

Article (Published version)

Identifiers

PID : unige:18209
DOI : 10.1002/anie.201107129

Journal ISSN1433-7851

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Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation

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