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Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation

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Published in Angewandte Chemie: International Edition. 2012, vol. 51, no. 4, p. 1055-1058
Abstract A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.
Keywords AlkylationAsymmetric catalysisCopperEnynesGrignard reagents
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Other version: http://doi.wiley.com/10.1002/anie.201107129
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LI, Hailing, ALEXAKIS, Alexandre. Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 4, p. 1055-1058. https://archive-ouverte.unige.ch/unige:18209

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Deposited on : 2012-01-27

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