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Title

Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation
Authors
Li, Hailing
Alexakis, Alexandre
Published in Angewandte Chemie. 2012, vol. 51, no. 4, p. 1055-1058
Abstract A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.
Keywords Alkylation — Asymmetric catalysis — Copper — Enynes — Grignard reagents
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Article (Published version) (364 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section de chimie et biochimie / Département de chimie organique
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(ISO format) 		LI, Hailing, ALEXAKIS, Alexandre. Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation. In: Angewandte Chemie, 2012, vol. 51, n° 4, p. 1055-1058. doi: 10.1002/anie.201107129 https://archive-ouverte.unige.ch/unige:18209

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Deposited on : 2012-01-27

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