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Scientific Article
unige:18209 
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Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation |
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| Published in | Angewandte Chemie: International Edition. 2012, vol. 51, no. 4, p. 1055-1058 | |
| Abstract | A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides. | |
| Keywords | Alkylation — Asymmetric catalysis — Copper — Enynes — Grignard reagents | |
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| Citation (ISO format) | LI, Hailing, ALEXAKIS, Alexandre. Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 4, p. 1055-1058. doi: 10.1002/anie.201107129 https://archive-ouverte.unige.ch/unige:18209 |
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