In recent years, significant advancements were seen in implant prosthodontics with the further development of CAD/CAM technologies, introduction of new restorative materials and clinical workflows. This thesis is based on a research line regarding the mechanical and bonding stability of modern CAD/CAM restorative materials supported by titanium base abutments, with the goal to optimize material selection and procedures to improve clinical outcomes. The use of these new CAD/CAM materials enables the creation of personalized restorative solutions by integrating them with standard prosthetic components, such as titanium bases, within a comprehensive digital workflow. This research line is divided in two parts. The first part focused on the mechanical stability of the components, with the performance of thermo-mechanical dynamic fatigue in a chewing simulator followed by fracture tests in order to evaluate the stability of concept of hybrid abutments (titanium-base + meso-abutment + crown – Publication 1 (1)) and hybrid abutment-crowns (titanium base + abutment-crown – Publication 2 (2)). These studies demonstrated the titanium base abutments can withstand loading within the range of chewing forces expected in the oral cavity, similarly to other conventional abutments. However, the presence of micro-movements was detected between abutment-crowns and titanium bases which could have biological impact on the peri-implant tissues. This finding reinforced the need for optimization of the bonding protocol, and led to the second part of the research focused on titanium base surface treatments (Publication 3 (3)) and bonding protocol selection (Publication 4 (4)) for definitive restorations and as well for temporary restorations (Publication 5 (5)). In these studies, pull-off tests were performed after a dynamic aging protocol. These studies provided the recommendation to previously sandblast the titanium base abutment surface with 50-μm Al2O3 particles and then select the adequate bonding system, which depends on the ceramic material used for the restoration. Lastly, an optimization of the bonding protocol of temporary restorations on titanium bases was also provided by a modification of the manufacturer recommended protocol.