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Impaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease

Ludwiczek, Othmar
Vannier, Edouard
Moschen, Alexander
Salazar-Montes, Adriana
Borggraefe, Ingo
Enrich, Barbara
Kaser, Arthur
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Published in Scandinavian Journal of Gastroenterology. 2008, vol. 43, no. 11, p. 1360-1365
Abstract OBJECTIVE: To assess the production of the endogenous IL-1 modulators IL-1 receptor antagonist (IL-1Ra), type I and II soluble IL-1 receptors (IL-1sRI and II) in patients with chronic liver disease (CLD). MATERIAL AND METHODS: Plasma levels of IL-1beta (IL-1beta) and IL-1 modulators were assessed in 126 CLD patients and 39 healthy controls. IL-1sRII was also measured in the supernatants of primary hepatocyte cultures. RESULTS: Plasma IL-1sRI and IL-1Ra levels were significantly higher in cirrhotic CLD patients than in non-cirrhotic CLD patients and in controls. Levels did not depend on the etiology of CLD. Likewise, plasma IL-1beta levels were elevated in CLD patients compared with those in controls. In contrast, IL-1sRII levels did not differ between CLD patients and controls. Cultures of human primary hepatocytes showed that IL-1sRII is induced by IL-1beta, but not IL-6. CONCLUSIONS: In cirrhotic CLD patients elevated plasma IL-1beta is not counteracted by endogenous levels of IL-1sRII, whereas high IL-1sRI is expected to neutralize the naturally occurring antagonist IL-1Ra, resulting in a dysregulation of the IL-1 system that might enhance pro-inflammatory activity of IL-1.
Keywords AdultAgedCase-Control StudiesChronic DiseaseFemaleHumansInterleukin-1beta/blood/metabolismLiver Cirrhosis/metabolismLiver Diseases/metabolismMaleMiddle AgedReceptors, Interleukin-1 Type I/biosynthesis/bloodReceptors, Interleukin-1 Type II/biosynthesis/blood
PMID: 18609176
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Research group Mécanisme de l'inflammation articulaire (44)
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LUDWICZEK, Othmar et al. Impaired counter-regulation of interleukin-1 by the soluble IL-1 receptor type II in patients with chronic liver disease. In: Scandinavian Journal of Gastroenterology, 2008, vol. 43, n° 11, p. 1360-1365. https://archive-ouverte.unige.ch/unige:1817

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Deposited on : 2009-05-28

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