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IL-1, IL-18, and IL-33 families of cytokines

Arend, William P.
Published in Immunological reviews. 2008, vol. 223, no. 1, p. 20-38
Abstract SUMMARY: The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. All three cytokines are synthesized as precursor molecules and cleaved by the enzyme caspase-1 before or during release from the cell. The NALP-3 inflammasome is of crucial importance in generating active caspase-1. The IL-1 family contains two agonists, IL-1alpha and IL-1beta, a specific inhibitor, IL-1 receptor antagonist (IL-1Ra), and two receptors, the biologically active type IL-1R and inactive type II IL-1R. Both IL-1RI and IL-33R utilize the same interacting accessory protein (IL-1RAcP). The balance between IL-1 and IL-1Ra is important in preventing disease in various organs, and excess production of IL-1 has been implicated in many human diseases. The IL-18 family also contains a specific inhibitor, the IL-18-binding protein (IL-18BP), which binds IL-18 in the fluid phase. The IL-18 receptor is similar to the IL-1 receptor complex, including a single ligand-binding chain and a different interacting accessory protein. IL-18 provides an important link between the innate and adaptive immune responses. Newly described IL-33 binds to the orphan IL-1 family receptor T1/ST2 and stimulates T-helper 2 responses as well as mast cells.
Keywords Interleukin-1Interleukin-18Interleukin-33CytokinesInflammatory diseases
PMID: 18613828
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Research group Mécanisme de l'inflammation articulaire (44)
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AREND, William P., PALMER-LOURENCO, Gaby, GABAY, Cem. IL-1, IL-18, and IL-33 families of cytokines. In: Immunological reviews, 2008, vol. 223, n° 1, p. 20-38. https://archive-ouverte.unige.ch/unige:1816

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Deposited on : 2009-05-28

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