IL-1, IL-18, and IL-33 families of cytokines

Arend, William P.; Palmer-Lourenco, Gaby; Gabay, Cem

doi:10.1111/j.1600-065X.2008.00624.x

Scientific article

English

IL-1, IL-18, and IL-33 families of cytokines

Contributors

Arend, William P.; Palmer-Lourenco, Gaby

; Gabay, Cem

Published in

Immunological reviews, vol. 223, no. 1, p. 20-38

Publication date

2008

Abstract

The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. All three cytokines are synthesized as precursor molecules and cleaved by the enzyme caspase-1 before or during release from the cell. The NALP-3 inflammasome is of crucial importance in generating active caspase-1. The IL-1 family contains two agonists, IL-1alpha and IL-1beta, a specific inhibitor, IL-1 receptor antagonist (IL-1Ra), and two receptors, the biologically active type IL-1R and inactive type II IL-1R. Both IL-1RI and IL-33R utilize the same interacting accessory protein (IL-1RAcP). The balance between IL-1 and IL-1Ra is important in preventing disease in various organs, and excess production of IL-1 has been implicated in many human diseases. The IL-18 family also contains a specific inhibitor, the IL-18-binding protein (IL-18BP), which binds IL-18 in the fluid phase. The IL-18 receptor is similar to the IL-1 receptor complex, including a single ligand-binding chain and a different interacting accessory protein. IL-18 provides an important link between the innate and adaptive immune responses. Newly described IL-33 binds to the orphan IL-1 family receptor T1/ST2 and stimulates T-helper 2 responses as well as mast cells.

Keywords

Interleukin-1
Interleukin-18
Interleukin-33
Cytokines
Inflammatory diseases

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

UNIGE research groups

Citation (ISO format)

AREND, William P., PALMER-LOURENCO, Gaby, GABAY, Cem. IL-1, IL-18, and IL-33 families of cytokines. In: Immunological reviews, 2008, vol. 223, n° 1, p. 20–38. doi: 10.1111/j.1600-065X.2008.00624.x

Article (Accepted version)

Identifiers

PID : unige:1816
DOI : 10.1111/j.1600-065X.2008.00624.x
PMID : 18613828

Journal ISSN

0105-2896

930views

4108downloads

Creation

28/05/2009 12:25:00

First validation

28/05/2009 12:25:00

Update

26/03/2026 10:38:47

Status update

26/03/2026 10:38:47

Last indexation

26/03/2026 10:43:44

IL-1, IL-18, and IL-33 families of cytokines

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation