UNIGE document Scientific Article
previous document  unige:18095  next document
add to browser collection
Title

Mechanisms of oral permeation enhancement

Authors
Ganem-Quintanar, A.
Falson-Rieg, F.
Published in International Journal of Pharmaceutics. 1997, vol. 156, no. 2, p. 127-142
Abstract This paper reviews the effects of a diverse range of penetration enhancers, including fatty acids, bile salts, surfactants, Azone® and ethanol, on oral mucosa. We describe in detail the effects on the intercellular lipid domains, the changes induced in proteinaceous regions and potential interactions between the enhancer and endogenous structures along the transport pathway. Since there have been few structure-based studies of the oral mucosa, which have discussed enhancer effect as a function of specific physicochemical properties, we have drawn upon analogous studies of skin and other mucosal membranes, as well as model lipid systems, e.g. liposomes.
Keywords Oral mucosaLipid organizationPermeation enhancers
Identifiers
Full text
Structures
Citation
(ISO format)
GANEM-QUINTANAR, A. et al. Mechanisms of oral permeation enhancement. In: International Journal of Pharmaceutics, 1997, vol. 156, n° 2, p. 127-142. https://archive-ouverte.unige.ch/unige:18095

191 hits

0 download

Update

Deposited on : 2012-01-17

Export document
Format :
Citation style :