Purpose: Positron emission tomography (PET) with the first and only tau targeting radiotracer of¹⁸F-flortaucipir approved by FDA has been increasingly used in depicting tau pathology deposition and distribution in patients with cognitive impairment. The goal of this international consensus is to help nuclear medicine practitioners procedurally perform¹⁸F-flortaucipir PET imaging.

Method: A multidisciplinary task group formed by experts from various countries discussed and approved the consensus for¹⁸F-flortaucipir PET imaging in Alzheimer's disease (AD), focusing on clinical scenarios, patient preparation, and administered activities, as well as image acquisition, processing, interpretation, and reporting.

Conclusion: This international consensus and practice guideline will help to promote the standardized use of¹⁸F-flortaucipir PET in patients with AD. It will become an international standard for this purpose in clinical practice.