Scientific evidence highlights the pivotal role for structural change in pursuit of the sustainability transformation. A particular challenge for research on structural aspects of sustainable consumption and lifestyles, however, is the assessment of their impact. Especially quantifying the impact of structural change remains a serious problem. While some forms of structural change can be quantified, like the rate of building renovations, changes in the energy mix at the production level, or trends in access to health care or education, the impact of other changes such as societal narratives about wellbeing, political campaigns on energy technologies or policies, or the abandonment of the growth paradigm defy easy quantification. This article aims to shed light on potential avenues for quantitatively assessing the impact of structural change drawing on insights gained by a group of international and interdisciplinary research consortia funded by the European Union in the area of sustainable consumption, citizenship, and lifestyles research. It delineates strengths and weaknesses of different approaches, foci and blindspots of associated data types. Thereby, it highlights fundamental decisions that need to be made in research designs, but also important aspects to consider in the interpretation of results. Finally, the article highlights the particular challenges related to assessing the impact of deep political and ideational structures.