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Scientific article
English

Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters

Published inAngewandte Chemie, vol. 51, no. 3, p. 794-797
Publication date2012
Abstract

Not a cop out: The copper-catalyzed asymmetric conjugate addition of organometallic reagents to Michael acceptors is an important methodology for forming a CC bond in an enantioselective manner. Such an addition of Me3Al to β,γ-unsaturated α-ketoesters is described to proceed in high yield and selectivity. CuTC=copper(I) thiophene-2-carboxylate.

Keywords
  • Amino acids
  • Asymmetric catalysis
  • Copper
  • Enantioselectivity
  • Synthetic methods
Citation (ISO format)
GREMAUD, Ludovic, ALEXAKIS, Alexandre. Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters. In: Angewandte Chemie, 2012, vol. 51, n° 3, p. 794–797. doi: 10.1002/anie.201107324
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ISSN of the journal1433-7851
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Creation01/12/2012 9:50:00 AM
First validation01/12/2012 9:50:00 AM
Update time03/14/2023 5:06:49 PM
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