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Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters

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Published in Angewandte Chemie: International Edition. 2012, vol. 51, no. 3, p. 794-797
Abstract Not a cop out: The copper-catalyzed asymmetric conjugate addition of organometallic reagents to Michael acceptors is an important methodology for forming a CC bond in an enantioselective manner. Such an addition of Me3Al to β,γ-unsaturated α-ketoesters is described to proceed in high yield and selectivity. CuTC=copper(I) thiophene-2-carboxylate.
Keywords Amino acidsAsymmetric catalysisCopperEnantioselectivitySynthetic methods
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Other version: http://doi.wiley.com/10.1002/anie.201107324
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GREMAUD, Ludovic, ALEXAKIS, Alexandre. Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters. In: Angewandte Chemie: International Edition, 2012, vol. 51, n° 3, p. 794-797. https://archive-ouverte.unige.ch/unige:18073

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Deposited on : 2012-01-13

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