Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters

Gremaud, Ludovic; Alexakis, Alexandre

doi:10.1002/anie.201107324

Scientific article

English

Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters

ContributorsGremaud, Ludovic; Alexakis, Alexandre

Published inAngewandte Chemie, vol. 51, no. 3, p. 794-797

Publication date2012

Abstract

Not a cop out: The copper-catalyzed asymmetric conjugate addition of organometallic reagents to Michael acceptors is an important methodology for forming a CC bond in an enantioselective manner. Such an addition of Me3Al to β,γ-unsaturated α-ketoesters is described to proceed in high yield and selectivity. CuTC=copper(I) thiophene-2-carboxylate.

Keywords

Amino acids
Asymmetric catalysis
Copper
Enantioselectivity
Synthetic methods

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

GREMAUD, Ludovic, ALEXAKIS, Alexandre. Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters. In: Angewandte Chemie, 2012, vol. 51, n° 3, p. 794–797. doi: 10.1002/anie.201107324

Article (Published version)

Identifiers

PID : unige:18073
DOI : 10.1002/anie.201107324

ISSN of the journal1433-7851

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Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminium to β,γ-Unsaturated α-Ketoesters

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