Mediastinitis caused by an NDM-1 <i>Escherichia coli</i> in a child with Dacron® Sano shunt after pulmonary atresia with ventricular septal defect surgery treated with combination of aztreonam-avibactam

Cousin, Vladimir; Miatello, Jordi; Sierra, Roberto; Sologashvili, Tornike; Wacker Bou Puigdefabregas, Julie Caroline; Andrey, Diego Olivier; L'Huillier, Arnaud

doi:10.1016/j.ijantimicag.2024.107295

Scientific article

English

Mediastinitis caused by an NDM-1 Escherichia coli in a child with Dacron® Sano shunt after pulmonary atresia with ventricular septal defect surgery treated with combination of aztreonam-avibactam

ContributorsCousin, Vladimir; Miatello, Jordi; Sierra, Roberto; Sologashvili, Tornike; Wacker Bou Puigdefabregas, Julie Caroline; Andrey, Diego Olivier

; L'Huillier, Arnaud

Published inInternational journal of antimicrobial agents, vol. 64, no. 4, 107295

Publication date2024-10

First online date2024-08-02

Abstract

Carbapenem-resistant Enterobacterales are being increasingly reported and cause nosocomial infections, which may include post-operative mediastinitis. Here, we report a post-operative mediastinitis caused by an Escherichia coli NDM-1 carbapenemase producer in a 13-month boy with DiGeorge syndrome. The infection was managed with surgical debridement and antibiotherapy with aztreonam, ceftazidime-avibactam and IV fosfomycin for 6 weeks. The evolution was favorable without relapse with 10 weeks of follow-up.

Keywords

Aztreonam
Carbapenem-resistant Enterobacterales
Ceftazidime-avibactam
Mediastinitis
Pediatric
Post-surgical infection

Affiliation entities

Research groups

Citation (ISO format)

COUSIN, Vladimir et al. Mediastinitis caused by an NDM-1 Escherichia coli in a child with Dacron® Sano shunt after pulmonary atresia with ventricular septal defect surgery treated with combination of aztreonam-avibactam. In: International journal of antimicrobial agents, 2024, vol. 64, n° 4, p. 107295. doi: 10.1016/j.ijantimicag.2024.107295