Wide-Pulse High-Frequency Neuromuscular Electrical Stimulation (WPHF NMES) employs electrical impulses to depolarize intramuscular nerve branches, inducing torque via central and peripheral pathways. Reflexive motor unit recruitment with WPHF NMES is believed to be influenced by reinforcing Persistent Inward Currents (PICs) in spinal motoneuron dendrites, potentially activated by interventions like caffeine or remote contractions. This study aimed to assess the impact of caffeine and remote contraction on centrally-mediated responses to WPHF NMES. Ten participants (age = 27 ± 6 years, height = 177 ± 8 cm, mass = 69 ± 10kg) took part in a crossover, double-blind, randomized, placebo-controlled study. Three 10-s trains of WPHF NMES were applied to the triceps surae at an intensity eliciting 10% of the maximal voluntary contraction torque: before caffeine/placebo (6 mg.kg-1), 1h after ingestion and during a remote contraction. Triangular voluntary contraction of plantar flexors and dorsiflexors muscles were also performed and High-Density Electromyography was used to calculate the Delta F (paired motor unit technique). Results showed no change (P>0.05) in torque time integral following caffeine intake (Pre: 207.7 ± 113.1 Post: 221.6 ± 114) and remote contraction (257.2 ± 203.3). Delta F remained unaltered, except for a trend in the soleus muscle after caffeine ingestion (ΔPost-Pre-Control: -0.69 ± 0.84 ΔPost-Pre-Caffeine: 0.41 ± 1.6; P=0.053). Overall, the study did not show any clear effect of acute caffeine supplementation and remote contraction in modulating the torque evoked by WPHF NMES.