en
Scientific article
Open access
English

Using real-time modelling to inform the 2017 Ebola outbreak response in DR Congo

Published inNature communications, vol. 15, no. 1, 5667
Publication date2024-07-06
First online date2024-07-06
Abstract

Important policy questions during infections disease outbreaks include: i) How effective are particular interventions?; ii) When can resource-intensive interventions be removed? We used mathematical modelling to address these questions during the 2017 Ebola outbreak in Likati Health Zone, Democratic Republic of the Congo (DRC). Eight cases occurred before 15 May 2017, when the Ebola Response Team (ERT; co-ordinated by the World Health Organisation and DRC Ministry of Health) was deployed to reduce transmission. We used a branching process model to estimate that, pre-ERT arrival, the reproduction number was $$R=1.49$$ R = 1.49 (95% credible interval $$({{{{\mathrm{0.67,2.81}}}}})$$ ( 0.67, 2.81 ) ). The risk of further cases occurring without the ERT was estimated to be 0.97 (97%). However, no cases materialised, suggesting that the ERT’s measures were effective. We also estimated the risk of withdrawing the ERT in real-time. By the actual ERT withdrawal date (2 July 2017), the risk of future cases without the ERT was only 0.01, indicating that the ERT withdrawal decision was safe. We evaluated the sensitivity of our results to the estimated $$R$$ R value and considered different criteria for determining the ERT withdrawal date. This research provides an extensible modelling framework that can be used to guide decisions about when to relax interventions during future outbreaks.

eng
Keywords
  • Democratic Republic of the Congo / epidemiology
  • Disease Outbreaks / prevention & control
  • Ebolavirus
  • Hemorrhagic Fever, Ebola / epidemiology
  • Hemorrhagic Fever, Ebola / prevention & control
  • Humans
  • Models, Theoretical
Citation (ISO format)
THOMPSON, R. et al. Using real-time modelling to inform the 2017 Ebola outbreak response in DR Congo. In: Nature communications, 2024, vol. 15, n° 1, p. 5667. doi: 10.1038/s41467-024-49888-5
Main files (1)
Article (Published version)
Secondary files (1)
Identifiers
ISSN of the journal2041-1723
11views
2downloads

Technical informations

Creation07/10/2024 3:44:48 PM
First validation07/17/2024 2:54:27 PM
Update time07/22/2024 2:23:09 PM
Status update07/22/2024 2:23:09 PM
Last indexation07/22/2024 2:23:11 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack