Scientific article
OA Policy
English

Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing

Published ineLife, vol. 4, e07090
Publication date2015-06-23
First online date2015-06-23
Abstract

How tissue shape emerges from the collective mechanical properties and behavior of individual cells is not understood. We combine experiment and theory to study this problem in the developing wing epithelium of Drosophila. At pupal stages, the wing-hinge contraction contributes to anisotropic tissue flows that reshape the wing blade. Here, we quantitatively account for this wing-blade shape change on the basis of cell divisions, cell rearrangements and cell shape changes. We show that cells both generate and respond to epithelial stresses during this process, and that the nature of this interplay specifies the pattern of junctional network remodeling that changes wing shape. We show that patterned constraints exerted on the tissue by the extracellular matrix are key to force the tissue into the right shape. We present a continuum mechanical model that quantitatively describes the relationship between epithelial stresses and cell dynamics, and how their interplay reshapes the wing.

Keywords
  • D. melanogaster
  • Drosophila
  • Cell biology
  • Cell-dynamics
  • Computational biology
  • Continuum-mechanics
  • Morphogenesis
  • Systems biology
  • Tissue-mechanics
  • Wing-epithelium
Affiliation entities Not a UNIGE publication
Funding
  • Bundesministerium für Bildung und Forschung -
  • Max-Planck-Gesellschaft -
  • The Francis Crick Institute - [10317]
  • Cancer Research UK - [21144]
  • Seventh Framework Programme -
  • European Research Council -
Citation (ISO format)
ETOURNAY, Raphaël et al. Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophila pupal wing. In: eLife, 2015, vol. 4, p. e07090. doi: 10.7554/eLife.07090
Main files (1)
Article (Published version)
Identifiers
Additional URL for this publicationhttps://elifesciences.org/articles/07090
Journal ISSN2050-084X
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25downloads

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