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Scientific article
Open access
English

EEG Beta functional connectivity decrease in the left amygdala correlates with the affective pain in fibromyalgia : A pilot study

Published inPloS one, vol. 18, no. 2, e0281986
Publication date2023
First online date2023-02-21
Abstract

Fibromyalgia (FM) is a major chronic pain disease with prominent affective disturbances, and pain-associated changes in neurotransmitters activity and in brain connectivity. However, correlates of affective pain dimension lack. The primary goal of this correlational cross-sectional case-control pilot study was to find electrophysiological correlates of the affective pain component in FM. We examined the resting-state EEG spectral power and imaginary coherence in the beta (β) band (supposedly indexing the GABAergic neurotransmission) in 16 female patients with FM and 11 age-adjusted female controls. FM patients displayed lower functional connectivity in the High β (Hβ, 20-30 Hz) sub-band than controls (p = 0.039) in the left basolateral complex of the amygdala (p = 0.039) within the left mesiotemporal area, in particular, in correlation with a higher affective pain component level (r = 0.50, p = 0.049). Patients showed higher Low β (Lβ, 13-20 Hz) relative power than controls in the left prefrontal cortex (p = 0.001), correlated with ongoing pain intensity (r = 0.54, p = 0.032). For the first time, GABA-related connectivity changes correlated with the affective pain component are shown in the amygdala, a region highly involved in the affective regulation of pain. The β power increase in the prefrontal cortex could be compensatory to pain-related GABAergic dysfunction.

eng
Keywords
  • Humans
  • Female
  • Fibromyalgia
  • Pilot Projects
  • Cross-Sectional Studies
  • Magnetic Resonance Imaging / methods
  • Brain
  • Chronic Pain
  • Chronic Disease
  • Amygdala
  • Electroencephalography
Citation (ISO format)
MAKOWKA, Soline et al. EEG Beta functional connectivity decrease in the left amygdala correlates with the affective pain in fibromyalgia : A pilot study. In: PloS one, 2023, vol. 18, n° 2, p. e0281986. doi: 10.1371/journal.pone.0281986
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ISSN of the journal1932-6203
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