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Scientific article
Review
Open access
English

Vertex models: from cell mechanics to tissue morphogenesis

Published inPhilosophical transactions - Royal Society. Biological sciences, vol. 372, no. 1720, 20150520
Publication date2017-03-27
First online date2017-03-27
Abstract

Tissue morphogenesis requires the collective, coordinated motion and deformation of a large number of cells. Vertex model simulations for tissue mechanics have been developed to bridge the scales between force generation at the cellular level and tissue deformation and flows. We review here various formulations of vertex models that have been proposed for describing tissues in two and three dimensions. We discuss a generic formulation using a virtual work differential, and we review applications of vertex models to biological morphogenetic processes. We also highlight recent efforts to obtain continuum theories of tissue mechanics, which are effective, coarse-grained descriptions of vertex models.

This article is part of the themed issue ‘Systems morphodynamics: understanding the development of tissue hardware’.

eng
Keywords
  • Epithelial mechanics
  • Morphogenesis
  • Simulations
  • Tissue mechanics
  • Vertex models
Affiliation Not a UNIGE publication
Funding
  • Wellcome Trust - Theoretical Physics of Biology Laboratory [FC001317]
  • Cancer Research UK - [21144]
  • The Francis Crick Institute - [10317]
Citation (ISO format)
ALT, Silvanus, GANGULY, Poulami, SALBREUX, Guillaume. Vertex models: from cell mechanics to tissue morphogenesis. In: Philosophical transactions - Royal Society. Biological sciences, 2017, vol. 372, n° 1720, p. 20150520. doi: 10.1098/rstb.2015.0520
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal0962-8436
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