Scientific article
Case report
Open access

Relapses of Immune Thrombocytopenia after the Second and Booster Doses of BNT162b2 Vaccine

Published inActa haematologica, vol. 146, no. 1, p. 52-57
Publication date2023
First online date2022-11-03

We present here a 65-year-old male patient known for immune thrombocytopenic purpura (ITP) and fluctuating platelet count who experienced a severe exacerbation of thrombocytopenia following BNT162b2 COVID-19 vaccination. One month after the second dose, he presented petechiae and asthenia with isolated thrombocytopenia (platelet count: 3 × 109/L). He recovered after a 4-day course of intravenous corticosteroid treatment and intravenous immunoglobulin therapy. Eight months later, his platelet count was within the normal range, and he received a booster dose of vaccine after premedication with prednisone. Eight days later, his platelet count dropped to 29 × 109/L, but he remained asymptomatic. He received a rescue treatment with prednisone followed by rituximab over 4 weeks, allowing progressive improvement. Our case suggests a strong association between COVID-19 vaccination and the exacerbation of ITP.

  • COVID-19 mRNA vaccine
  • Immune thrombocytopenia
  • Platelet count
  • Safety
  • Surveillance
  • Aged
  • Humans
  • Male
  • BNT162 Vaccine
  • COVID-19 / prevention & control
  • COVID-19 Vaccines / adverse effects
  • Prednisone / therapeutic use
  • Purpura, Thrombocytopenic, Idiopathic / drug therapy
  • Purpura, Thrombocytopenic, Idiopathic / etiology
  • Recurrence
  • Thrombocytopenia / etiology
  • Thrombocytopenia / drug therapy
  • Vaccines / therapeutic use
Citation (ISO format)
RATAJCZAK-ENSELME, Maja et al. Relapses of Immune Thrombocytopenia after the Second and Booster Doses of BNT162b2 Vaccine. In: Acta haematologica, 2023, vol. 146, n° 1, p. 52–57. doi: 10.1159/000527431
Main files (1)
Article (Published version)
ISSN of the journal0001-5792

Technical informations

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