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Scientific article
Open access
English

Cardio-audio synchronization elicits neural and cardiac surprise responses in human wakefulness and sleep

Published inCommunications biology, vol. 7, no. 1, 226
Publication date2024-02-23
First online date2024-02-23
Abstract

The human brain can encode auditory regularities with fixed sound-to-sound intervals and with sound onsets locked to cardiac inputs. Here, we investigated auditory and cardio-audio regularity encoding during sleep, when bodily and environmental stimulus processing may be altered. Using electroencephalography and electrocardiography in healthy volunteers (N = 26) during wakefulness and sleep, we measured the response to unexpected sound omissions within three regularity conditions: synchronous, where sound and heartbeat are temporally coupled, isochronous, with fixed sound-to-sound intervals, and a control condition without regularity. Cardio-audio regularity encoding manifested as a heartbeat deceleration upon omissions across vigilance states. The synchronous and isochronous sequences induced a modulation of the omission-evoked neural response in wakefulness and N2 sleep, the former accompanied by background oscillatory activity reorganization. The violation of cardio-audio and auditory regularity elicits cardiac and neural responses across vigilance states, laying the ground for similar investigations in altered consciousness states such as coma and anaesthesia.

eng
Keywords
  • Humans
  • Wakefulness / physiology
  • Electroencephalography
  • Sleep / physiology
  • Brain / physiology
  • Sound
Citation (ISO format)
PELENTRITOU, Andria et al. Cardio-audio synchronization elicits neural and cardiac surprise responses in human wakefulness and sleep. In: Communications biology, 2024, vol. 7, n° 1, p. 226. doi: 10.1038/s42003-024-05895-2
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ISSN of the journal2399-3642
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