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Highly efficient desymmetrization of prochiral complexes: an entry to planar chiral scaffolds

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Defense Thèse de doctorat : Univ. Genève, 2011 - Sc. 4366 - 2011/10/21
Abstract Enantiomerically pure planar chiral complexes are of interest for both asymmetric synthesis and catalysis. In this thesis, we report on an easy access to highly enantioenriched neutral [Cr(CO)3(naphthalene)], [RuCp(indenyl)], [FeCp*(indenyl)] and cationic [RuCp*(naphthalene)] complexes via desymmetrization of prochiral dihalide complexes using a bulky chiral palladium catalyst. Ligand optimization and mechanistic analyses result in a clear picture of the reaction and the asymmetric induction. The potential utility of this reaction is illustrated in the synthesis of a ide range of highly enantioenriched planar chiral complexes. Particularly, the access to peri-palladacycles is of high interest in view of their evaluation in asymmetric catalysis.
Keywords PalladiumRuthenium complexesDesymmetrizationAsymmetric catalysisOrganometallic chemistry
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URN: urn:nbn:ch:unige-177471
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MERCIER, Audrey Catherine Marie. Highly efficient desymmetrization of prochiral complexes: an entry to planar chiral scaffolds. Université de Genève. Thèse, 2011. https://archive-ouverte.unige.ch/unige:17747

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Deposited on : 2011-12-07

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