Doctoral thesis
English

Highly efficient desymmetrization of prochiral complexes: an entry to planar chiral scaffolds

Defense date2011-10-21
Abstract

Enantiomerically pure planar chiral complexes are of interest for both asymmetric synthesis and catalysis. In this thesis, we report on an easy access to highly enantioenriched neutral [Cr(CO)3(naphthalene)], [RuCp(indenyl)], [FeCp*(indenyl)] and cationic [RuCp*(naphthalene)] complexes via desymmetrization of prochiral dihalide complexes using a bulky chiral palladium catalyst. Ligand optimization and mechanistic analyses result in a clear picture of the reaction and the asymmetric induction. The potential utility of this reaction is illustrated in the synthesis of a ide range of highly enantioenriched planar chiral complexes. Particularly, the access to peri-palladacycles is of high interest in view of their evaluation in asymmetric catalysis.

Keywords
  • Palladium
  • Ruthenium complexes
  • Desymmetrization
  • Asymmetric catalysis
  • Organometallic chemistry
Citation (ISO format)
MERCIER, Audrey Catherine Marie. Highly efficient desymmetrization of prochiral complexes: an entry to planar chiral scaffolds. Doctoral Thesis, 2011. doi: 10.13097/archive-ouverte/unige:17747
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Creation25/11/2011 15:54:00
First validation25/11/2011 15:54:00
Update time14/03/2023 17:05:32
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