Scientific article
English

Conformationally Stabilized Catalysts by Fluorine Insertion: Tool for Enantioselectivity Improvement

Published inChemistry, vol. 17, no. 48, p. 13433-13437
Publication date2011
Abstract

F rigid cats: The power of conformationally stabilized catalysts is demonstrated. By taking appropriate advantage of fluorine insertion (see scheme), purely conformational catalyst design led to a notable improvement in enantioselectivities from around 70 % to 91–98.5 % ee. The other advantage of this approach is the better understanding of the origin of the stereoselectivity in the given catalytic system.

Citation (ISO format)
QUINTARD, Adrien et al. Conformationally Stabilized Catalysts by Fluorine Insertion: Tool for Enantioselectivity Improvement. In: Chemistry, 2011, vol. 17, n° 48, p. 13433–13437. doi: 10.1002/chem.201102757
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Journal ISSN0947-6539
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