Scientific article
Open access

Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too

Published inEuropean journal of neurology, e16328
First online date2024-05-08

Background and purpose: Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disease resulting in progressive gait and cognitive disorders. We investigated whether the gait phenotype is associated with the severity of cognitive deficits in iNPH.

Methods: This retrospective study recruited 88 patients (mean age = 76.18 ± 7.21 years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.

Results: In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini-Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (β = -0.221 [95% confidence interval (CI) = -3.718 to -0.150], p = 0.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (β = 0.231 [95% CI = 0.124-3.639], p = 0.036).

Conclusions: Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.

  • Clinical evaluation
  • Cognition
  • Cognitive disorders
  • Gait
  • Normal pressure hydrocephalus
Citation (ISO format)
MOREL, Eric et al. Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too. In: European journal of neurology, 2024, p. e16328. doi: 10.1111/ene.16328
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Article (Published version)
ISSN of the journal1351-5101

Technical informations

Creation05/23/2024 5:22:04 AM
First validation05/27/2024 4:20:55 PM
Update time05/27/2024 4:20:55 PM
Status update05/27/2024 4:20:55 PM
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