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PET Imaging in Dementia : Mini-Review and Canadian Perspective for Clinical Use

Publication date2024-03-04
First online date2024-03-04
Abstract

PET imaging is increasingly recognized as an important diagnostic tool to investigate patients with cognitive disturbances of possible neurodegenerative origin. PET with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG), assessing glucose metabolism, provides a measure of neurodegeneration and allows a precise differential diagnosis among the most common neurodegenerative diseases, such as Alzheimer's disease, frontotemporal dementia or dementia with Lewy bodies. PET tracers specific for the pathological deposits characteristic of different neurodegenerative processes, namely amyloid and tau deposits typical of Alzheimer's Disease, allow the visualization of these aggregatesin vivo. [18F]FDG and amyloid PET imaging have reached a high level of clinical validity and are since 2022 investigations that can be offered to patients in standard clinical care in most of Canada.This article will briefly review and summarize the current knowledge on these diagnostic tools, their integration into diagnostic algorithms as well as perspectives for future developments.

eng
Keywords
  • Alzheimer’s disease
  • DOPA
  • Frontotemporal lobar degeneration
  • PET
  • Parkinsonism
  • SPECT
  • Amyloid
  • Dopamine transporters
  • Glucose metabolism
  • Tau
Citation (ISO format)
JUENGLING, Freimut et al. PET Imaging in Dementia : Mini-Review and Canadian Perspective for Clinical Use. In: Canadian journal of neurological sciences, 2024, p. 1–13. doi: 10.1017/cjn.2024.31
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ISSN of the journal0317-1671
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