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Scientific article
Case report
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Rheumatoid Arthritis Associated With Anti-Signal Recognition Particle Immune-Mediated Necrotizing Myopathy : A Case Report

Published inJournal of investigative medicine high impact case reports, vol. 12, 23247096241231646
Publication date2024
Abstract

Immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy that is characterized by severe subacute proximal weakness, myofiber necrosis, and significantly elevated serum creatine kinase. Anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase autoantibodies have been found in about two-thirds of patients with IMNM. This myopathy is usually idiopathic and there is a scarce literature concerning its association with connective tissue diseases. Herein, we report an unusual case of a young woman who presented with both rheumatoid arthritis and severe anti-SRP IMNM. Thankfully to a therapeutic protocol combining rituximab and cyclophosphamide, an important improvement was achieved, and notably no serious side effect was observed.

eng
Keywords
  • Anti-signal recognition particle antibodies
  • Cyclophosphamide
  • Immune-mediated necrotizing myopathy
  • Pathology
  • Rheumatoid arthritis
  • Rheumatology
  • Rituximab
  • Female
  • Humans
  • Signal Recognition Particle
  • Myositis / diagnosis
  • Myositis / drug therapy
  • Autoimmune Diseases
  • Muscular Diseases
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / drug therapy
Citation (ISO format)
BELKHRIBCHIA, Mohamed Reda et al. Rheumatoid Arthritis Associated With Anti-Signal Recognition Particle Immune-Mediated Necrotizing Myopathy : A Case Report. In: Journal of investigative medicine high impact case reports, 2024, vol. 12, p. 23247096241231646. doi: 10.1177/23247096241231646
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Article (Published version)
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ISSN of the journal2324-7096
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Creation05/17/2024 3:22:52 PM
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