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Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex

Published inTrends in parasitology, vol. 40, no. 5, p. 401-415
Publication date2024-05
Abstract

Microtubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heavily relies on the tubulin structures present in the apical complex. Recent advances in high-resolution imaging, coupled with reverse genetics, have offered deeper insights into the composition, functionality, and dynamics of these tubulin-based structures. The apicomplexan tubulins differ from those of their mammalian hosts, endowing them with unique attributes and susceptibility to specific classes of inhibitory compounds.

eng
Keywords
  • Apicomplexa
  • Toxoplasma gondii
  • Conoid
  • Dyneins
  • Kinesins
  • Microtubules
  • Tubulin
Citation (ISO format)
TELL I PUIG, Albert, SOLDATI-FAVRE, Dominique. Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex. In: Trends in parasitology, 2024, vol. 40, n° 5, p. 401–415. doi: 10.1016/j.pt.2024.02.010
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ISSN of the journal1471-4922
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