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Scientific article
Review
Open access
English

The Two-Way Route between Delirium Disorder and Dementia: Insights from COVID-19

Published inNeurodegenerative diseases, vol. 22, no. 3-4, p. 91-103
Publication date2022
First online date2023-04-13
Abstract

Background: Delirium disorder is a frequent neurological complication of SARS-CoV-2 infection and associated with increased disease severity and mortality. Cognitive impairment is a major risk factor for developing delirium disorder during COVID-19, which, in turn, increases the risk of subsequent neurological complications and cognitive decline.

Summary: The bidirectional connection between delirium disorder and dementia likely resides at multiple levels, and its pathophysiological mechanisms during COVID-19 include endothelial damage, blood-brain barrier dysfunction, and local inflammation, with activation of microglia and astrocytes. Here, we describe the putative pathogenic pathways underlying delirium disorder during COVID-19 and highlight how they cross with the ones leading to neurodegenerative dementia.

Key messages: The analysis of the two-sided link can offer useful insights for confronting with long-term neurological consequences of COVID-19 and framing future prevention and early treatment strategies.

eng
Keywords
  • Acute encephalopathy
  • COVID-19
  • Delirium
  • Dementia
  • Neurodegeneration
  • Neurovascular unit
  • SARS-CoV-2
Citation (ISO format)
BOMMARITO, Giulia et al. The Two-Way Route between Delirium Disorder and Dementia: Insights from COVID-19. In: Neurodegenerative diseases, 2022, vol. 22, n° 3-4, p. 91–103. doi: 10.1159/000530566
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Article (Published version)
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ISSN of the journal1660-2854
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