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Scientific article
English

Stability and Roughness of Interfaces in Mechanically Regulated Tissues

Published inPhysical review letters, vol. 121, no. 23
Publication date2018-12-07
First online date2018-12-07
Abstract

Cell division and death can be regulated by the mechanical forces within a tissue. We study the consequences for the stability and roughness of a propagating interface by analyzing a model of mechanically regulated tissue growth in the regime of small driving forces. For an interface driven by homeostatic pressure imbalance or leader-cell motility, long and intermediate-wavelength instabilities arise, depending, respectively, on an effective viscosity of cell number change, and on substrate friction. A further mechanism depends on the strength of directed motility forces acting in the bulk. We analyze the fluctuations of a stable interface subjected to cell-level stochasticity, and find that mechanical feedback can help preserve reproducibility at the tissue scale. Our results elucidate mechanisms that could be important for orderly interface motion in developing tissues.

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Affiliation Not a UNIGE publication
Funding
  • Wellcome Trust - Theoretical Physics of Biology Laboratory [FC001317]
  • Wellcome Trust - Apoptosis and Proliferation Control Laboratory [FC001175]
  • Cancer Research UK - [21144]
  • The Francis Crick Institute - [10687]
  • Francis Crick Institute -
Citation (ISO format)
WILLIAMSON, John J., SALBREUX, Guillaume. Stability and Roughness of Interfaces in Mechanically Regulated Tissues. In: Physical review letters, 2018, vol. 121, n° 23. doi: 10.1103/PhysRevLett.121.238102
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Article (Published version)
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ISSN of the journal0031-9007
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