Scientific article

Stability and Roughness of Interfaces in Mechanically Regulated Tissues

Published inPhysical review letters, vol. 121, no. 23
Publication date2018-12-07
First online date2018-12-07

Cell division and death can be regulated by the mechanical forces within a tissue. We study the consequences for the stability and roughness of a propagating interface by analyzing a model of mechanically regulated tissue growth in the regime of small driving forces. For an interface driven by homeostatic pressure imbalance or leader-cell motility, long and intermediate-wavelength instabilities arise, depending, respectively, on an effective viscosity of cell number change, and on substrate friction. A further mechanism depends on the strength of directed motility forces acting in the bulk. We analyze the fluctuations of a stable interface subjected to cell-level stochasticity, and find that mechanical feedback can help preserve reproducibility at the tissue scale. Our results elucidate mechanisms that could be important for orderly interface motion in developing tissues.

Affiliation Not a UNIGE publication
  • Wellcome Trust - Theoretical Physics of Biology Laboratory [FC001317]
  • Wellcome Trust - Apoptosis and Proliferation Control Laboratory [FC001175]
  • Cancer Research UK - [21144]
  • The Francis Crick Institute - [10687]
  • Francis Crick Institute -
Citation (ISO format)
WILLIAMSON, John J., SALBREUX, Guillaume. Stability and Roughness of Interfaces in Mechanically Regulated Tissues. In: Physical review letters, 2018, vol. 121, n° 23. doi: 10.1103/PhysRevLett.121.238102
Main files (1)
Article (Published version)
ISSN of the journal0031-9007

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