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Scientific article
Open access
English

Outcome measures for Alzheimer's disease : A global inter-societal Delphi consensus

Published inAlzheimer's & dementia, vol. 19, no. 6, p. 2707-2729
Publication date2023-06
First online date2023-02-07
Abstract

Introduction: We aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome.

Methods: A consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria.

Results: Consensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes.

Discussion: This work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.

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Keywords
  • Alzheimer's disease
  • Delphi
  • Consensus
  • Dementia
  • Measures
  • Outcomes
  • Humans
  • Alzheimer Disease / therapy
  • Alzheimer Disease / diagnosis
  • Quality of Life
  • Delphi Technique
  • Outcome Assessment, Health Care
Citation (ISO format)
ELLISON, Tim S et al. Outcome measures for Alzheimer’s disease : A global inter-societal Delphi consensus. In: Alzheimer’s & dementia, 2023, vol. 19, n° 6, p. 2707–2729. doi: 10.1002/alz.12945
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ISSN of the journal1552-5260
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